has role relateds assay has related human gene family of ATF in vitro assay ATF3 inhibitor of tumor cell activity role ER stress dependent molecule (human in vitro) ATF3 (human)[ER stress] PERK->ATF4->ATF3 reactome PMID:20485437 PMID:22046379 PMID:24939851 PMID:26917416 PMID:27484784 PMID:8622660 This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011] stress induction ->ATF3 ->apotosis induction by activating pro-apoptic genesTNRSF1-B and BBC3 cancer development ->ATF3 ->apoptosis inhibition by repressing proapoptic genes CDKN1A Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PMID:22046379 Stress-induced ATF3 binds to 40% of p53 targets and activates pro-apoptotic genes such as TNFRSF10B/DR5 and BBC3/PUMA. Cancer-associated ATF3, by contrast, represses these pro-apoptotic genes in addition to CDKN1A/p21. ATF3 has opposing, cell context-dependent effects on p53 target genes in DNA damage response and cancer development. NCBI-Human-GeneID:467 transcription factor ATF3 (mol)