has part occurs in has result has context cytoplasm endoplasmic reticulum-associated degradation retrograde protein transport from ER to cytosol [ER stress] protein catabolic process [ER stress] ER stress dependent process ER-associated misfolded protein catabolic process [ER stress] The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This entity is a specific course-dependent process. This process can constitute the course of ER stress. abnormal protein production- degradation imbalance [ER stress] endoplasmic reticulum stress [toxic course]