has participant has result has context apoptotic process glutathione depletion [toxic course] glutathione depletion dependent process Mdm2 (rat)[Glutathione depletion] apoptotic process [Glutathione depletion] A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. This entity is a specific course-dependent process. This process can constitute the course of Glutathione depletion. PMID:19662025 increasing number of dead cells in liver [Glutathione depletion]