has part has core process toxic course accumulation of compound in ER [ER stress] autophagy [ER stress] liver dysfunction [ER stress] protein quality control for unfolded via gene expression regulation [ER stress] accumulation of abnormal proteins in ER [ER stress (severe) ] increasing number of dead cells in liver [ER stress] positive regulation of ERAD [ER stress] positive regulation of protein refolding [ER stress] apoptotic process [ER stress] endoplasmic reticulum stress response imbalance [ER stress] attenuation of translation [ER stress] endoplasmic reticulum dysfunction [ER stress] tumorigenesis [ER stress] inflammatory response [ER stress] tumor growth [ER stress] hepatic fibrosis [ER stress] cell proliferation [ER stress] positive regulation of autophagy [ER stress] malfunction of mitochondria [ER stress] negative regulation of glycosylation [ER stress] accumulation of abnormal proteins in ER [ER stress (mild) ] positive regulation of apoptotic process [ER stress] cell cycle arrest [ER stress] protein unfolding [ER stress] hypofunction of mitochondrial fatty acid beta-oxidation [ER stress] lipid storage in liver [ER stress] protein refolding (sustained) [ER stress] hypofunction of carbohydrate metabolism [ER stress] hypofunction of drug metabolism [ER stress] hypofunction of sequestering of calcium ion [ER stress] malfunction of lipid biosynthesis [ER stress] malfunctioning of cellular membrane [ER stress] necrosis [ER stress] insulin resistance (process) [ER stress] ER-associated misfolded protein catabolic process [ER stress] protein refolding [ER stress (early stage)] hypofunction of ATP biosynthesis [ER stress] refolding-unfolding imbalance [ER stress (mild) ] refolding-unfolding imbalance [ER stress (moderate) ] accumulation of abnormal proteins in ER [ER stress (moderate) ] abnormal protein production- degradation imbalance [ER stress] hyperfunction of protein unfolding (sustained) [ER stress] accumulation of compound in ER [ER stress (severe) ] protein aggregation [ER stress] endoplasmic reticulum stress [toxic course] ER stress [toxic course] MeSH:D059865 PMID:17765679 PMID:22883813 PMID:23022383 PMID:23334697 PMID:26977301 The ER stress is a cellular response that occurs after sustained pertubation of ER protein synthesis, folding, and export machinery. Tis is likely to be induced by oxidative or covalent modification of ER proteins, which leads to misfolding of proteins. The totality of all processes through which endoplasmic reticulum (ER) stress is realized. aggregated protein production- degradation imbalance [ER stress] increasing number of abnormal cells in liver [ER stress] hyperfunction of cell survival[ER stress] carcinogenesis [ER stress] tumor cell proliferation [ER stress] protein quality control for unfolded proteins [ER stress (early stage)] protein quality control for unfolded proteins [ER stress] positive regulation of cellular response to oxidative stress [ER stress] enabling translation [ER stress] changing calcium ion concentration in ER [ER stress] hypofunction of phospholipid transport from ER to mitochondrial membrane [ER stress] malfunction of phospholipid biosynthesis [ER stress] tumor cell survial [ER stress] maintaining cell survival-cell death balance [ER stress]