has part has pathway IRE1 signaling (integrated pathway) IRE1-Traf2-ASK-JNK-AP1 pathway [ER stress - inflammation] IRE1-TRAF2-ASK1 complex A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). http://purl.obolibrary.org/obo/GO_1990604 IRE1-Traf2-ASK-JNK-AP1 pathway is a subtype of IRE1 signaling (integrated pathway): Sequence of linked reactions, which has IRE1-Traf2-ASK-JNK signaling and gene regulation by AP1. This pathway is dependent on the inflammation and can constitute the course of ER stress. PMID:27346803 TRAF2 activation by IRE1 [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway] ASK activation [ER stress - inflammation] JNK activation [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway] inflammatory cytokine gene expression by AP-1 [ER stress - inflammation] IRE1 pathway [ER stress - inflammation - IRE1-JNK pathway]