has part has pathway IRE1 signaling (integrated pathway) ERAD gene expression by XBP1 [ER stress] IRE1-XBP1 mediated pathway [ER stress - ERAD] IRE1-XBP1 mediated pathway is a subtype of IRE1 signaling (integrated pathway): Sequence of linked reactions, which has IRE1 signaling and gene regulation by XBP1. This process is dependent on ERAD and can constitute the course of ER stress. IRE1 signaling to XBP1 [ER stress] receiving abnormal protein signal by IRE1 [ER stress - ERAD] IRE1 pathway [ER stress - ERAD] XBP1s gene regulation pathway [ER stress - ERAD]