has context has agent phospholipid efflux cholestasis dependent process cholestasis [toxic course] phospholipid efflux (from heptocyte menbrane to canaliculus) [cholestasis] A release process of the phospholipids from one side of a membrane of hepatocyte to the other side of canaliculus. This entity is a specific course-dependent process. This process can constitute the course of Cholestasis. Bile is rich in phospholipids and organic anions such as bilirubin conjugates. Phospholipids are the main component of biliary lipids and need MFR3 (multidrug resistance protein 3, ABCB4) to enter the canalicular bile . This ABC transporter translocates the main biliary lipid phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Bile salts, by acting as detergents, release phosphatidylcholine from the outer can canalicular leaflet into the canaliculus. Cholesterol release from the canalicular membrane it; in part mediated by the heterodimeric ABC transporter ABCG5/ABCG8 (ABCG5/ABCG8) Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids. ABCB4 (canonical)[Cholestasis]