has context cholestasis dependent process cholestasis [toxic course] bile secretion (from heptocyte menbrane to canaliculus) [cholestasis] A release process of the bile from one side of a membrane of hepatocyte to the other side of canaliculus druing the cholestasis. This entity is a specific course-dependent process. This process can constitute the course of Cholestasis. Bile circulation (whole body): From the blood vessel side (sinusoidal side) -> hepatocyte ttransport -> bile secretion/excretion from the bile duct side membrane to the capillary bile duct, then to the bile duct, duodenum, intestinal hepatic circulation. Hepatocytes have polarity and have transporters in the membranes on the side of the sinusoidal side and the bile duct. Sinusoid side: OATP family (OATP 1 B 1, OATP 1 B 3): organic anion NTCP: Na dependent uptake MRP 3, 4: Excretion of organic anion from inside the liver into sinusoids Bile duct membrane side: BSEP (ABCG 11): (amino acid conjugation) excretion of bile acid into the bile canaliculi MRP 2: Excretion of organic anions such as sulfate conjugated bile acid, glucuronic acid conjugated bile acid, conjugated bilirubin MDR1: cation excretion MDR 3: phospholipid excretion ABCG 5 / ABCG 8: cholesterol excretion Export into the canaliculus is mediated by the BSEP (bile salt export pump, ABCB11) . bile secretion to bile canaliculus