has context has agent cholestasis dependent process cholestasis [toxic course] oranic anion export (from heptocyte menbrane to canaliculus) [cholestasis] A release process of organic anions from one side of a membrane of hepatocyte to the other side of canaliculus. This entity is a specific course-dependent process. This process can constitute the course of Cholestasis. Biliary organic anions other than bile salts are mainly conjugates of bilirubin and GSH. Drug metabolites excreted into bile are also organic anions, which are transported by the two ABC transporters, MRP2 (canalicular multi specific organic anion transport 1/multi drug resistance-associated protein 2, ABCC2) and ABCG2 (ABCG2). Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2). MRP2 (canonical)[Cholestasis] ABCG2 (canonical)[Cholestasis] oranic anion export