has role cholestasis dependent molecule (canonical) transcription regulator FXR (canonical)[Cholestasis] Bile salts activate a bile sil sensor, FXR (bile acid receptor; NR1H4) in hepatocytes. FARNESOID X-ACTIVATED RECEPTOR [cholestasis] PMID:26888176 UniProt:Q96RI1 bile acid receptor [cholestasis] http://purl.bioontology.org/ontology/MESH/C094063 https://omim.org/entry/603826 NCBI-Rat-GeneID:60351 http://www.ncbi.nlm.nih.gov/gene/9971 NCBI-Mouse-GeneID:20186 NCBI-Human-GeneID:9971 FXR (mol)