has context cholestasis dependent process cholestasis [toxic course] negative regularuion of bile acid and bile salt transport [Cholestasis] FXR regulates of metabolic processes. Activation of FXR by increased bile salt concentrations in hepatocytes downregulates the uptake systems for bile salts and maintains or upregulates bill salt efflux systems Negative regularuion of bile acid and bile salt transport is a subtype of negative regulation of transport: Any process that stops, prevents, or reduces the frequency, rate or extent of a bile acid and bile salts transport . This entity is a specific course-dependent process. This process can constitute the course of Cholestasis. トランスポーター遺伝子の発現を変えることで阻害 negative regularuion of bile acid and bile salt transport