negatively regulates has result has context has agent bosentan [Cholestasis] cholestasis dependent process bile acid accumulation in hepatocyte [Cholestasis] troglitazone [Cholestasis] cholestasis [toxic course] rifampicin [Cholestasis] negative regulation of bile acid and bile salts export from the hepatocyte bile secretion (from heptocyte menbrane to canaliculus) [cholestasis] negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis] Export into the canaliculus is mediated by the BSEP (bile salt export pump, ABCB11) . Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP). Negative regulation of bile acid and bile salts export from the hepatocyte to bile tube is a subtype of negative regulation of transport: A process that stops, prevents, or reduces the frequency, rate or extent of bile acid and bile salts export from the hepatocyte to the bile tube. This entity is a specific course-dependent process. This process can constitute the course of Cholestasis.