has part dissociation of NF-kappaB-I-kappaB ubiquitination of IkB [NfKB pathway] degradation of IKB [NfkB pathway] dissociation of NF-kappaB - IkappaB [NfKB pathway] Dissociation of NF-kappaB -I-kappaB is a subtype of detaching: A process that disaggregates a NF-kappaB-I-kappaB to NF-kappaB dimers and I-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. This entity is a specific course-dependent process. This process can constitute the course of NfKB pathway. PMID:15134788 http://purl.obolibrary.org/obo/IEV_0000215 I-kappaB phosphorylation [ER stress - inflammation - IRE1-NfkB pathway]