has part has pathway PERK-eIF2a signaling (integrated pathway) PERK-eIF2a-NFkB pathway [ER stress - inflammation] PERK-eIF2a-NFkB pathway is a subtype of PERK-eIF2a signaling: Sequence of linked reactions, which has PERK-eIF2a signaling and gene regulation by NF-kappa B. This pathway is dependent on the inflammation and can constitute the course of ER stress. PMID:15542827 PMID:20303879 PMID:28860159 PERK-eIF2a signaling [ER stress - inflammation] NF-kappaB activation [ER stress - inflammation] regulation of gene expression by NfKB [ER stress - inflammation - PERK-eIF2a-NfkB pathway] Translocation of NF-kappaB from the Cytosol to the Nucleus [ER stress - inflammation - Perk-eIF2a-NfkB pathway] attenuation of I-kappaB translation by eIF2a [ER stress - inflammation]