has part has pathway I-kappaB kinase/NF-kappaB signaling IRE1 signaling (integrated pathway) IRE1-TRAF2-NFkB signal transduction pathway [ER stress - inflammation] IRE1-TRAF2-NFkB signal transduction pathway is a subtype of IRE1 signaling (integrated pathway): Sequence of linked reactions, which has IRE1-TRAF2 signaling and gene regulation by NF-kappaB. This pathway is dependent on the inflammation and can constitute the course of ER stress. PMID:12843613 PMID:20303879 PMID:25232821 NF-kappaB activation [ER stress - inflammation - IRE1-TRAF2-IkB-NfkB pathway] regulation of gene expression by NfKB [ER stress - inflammation - IRE1-Traf2-NfkB pathway] Translocation of NF-kappaB from the Cytosol to the Nucleus [ER stress - inflammation - IRE1-TRAF2-NfkB pathway] TRAF2 activation by IRE1 [ER stress - inflammation - IRE1-TRAF2-IKK-NfkB pathway] IKK activation [ER stress - inflammation - IRE1-TRAF2-NfkB pathway] IRE1 pathway [ER stress - inflammation - IRE1-NfkB pathway]