has part has context PERK-eIF2a signaling (integrated pathway) attenuation of translation [ER stress] inflammatory response [ER stress] PERK-eIF2a signaling [ER stress - inflammation] PERK-eIF2a signaling is a subtype of PERK signaling (integrated pathway): Sequence of linked reactions, which has PERK-eIF2a signaling and gene regulation pathway. This pathway is dependent on the inflammation and can constitute the course of ER stress. receiving abnormal protein signal by PERK [ER stress - inflammation] PERK signaling to eIF2a [ER stress - inflammation] attenuation of I-kappaB translation by eIF2a [ER stress - inflammation]