decreasing I-kappaB production decreasing I-kappaB production [ER stress - inflammation -Perk-eIF2a-NfkB] Decreasing I-kappaB production is a subtype of decreasing production quantity of protein: A process that changes the quantity of the Iinhibitor of kappa B (I-kappaB) to be lower. This process is dependent on the Perk-eIF2a-NfkB pathway mediated inflammation and can constitute the course of ER stress. PMID:22249202 PMID:25232821