has output has result has context molecular activation endoplasmic reticulum stress [toxic course] IKK activation [ER stress - inflammation - IRE1-TRAF2-NfkB pathway] TRAF2 -IRE1 adaptor protein (canonical)[ER stress - inflammation -IRE1-NfkB] TRAF2 activation by IRE1 PMID:25232821 TRAF2 activation by IRE1 is a subtype of molecular activation: A process that changes the activity of the TARF2 to be higher by IRE1. ER stress dependent process (molecular level)