has input has output has result BIP-IRE1 complex (canonical)[ER stress] Dissociation of IRE1:BIP Heterodimer [ER stress] PERK - stress sensor (canonical)[ER stress - inflammation] PERK dimerization [ER stress - inflammation] Dissociation of IRE1:BIP Heterodimer [ER stress - inflammation] Dissociation of IRE1:BIP heterodimer is a subtype of detaching: A process that disaggregates IRE-1-BIP heterodimers into BIP and IRE1. This process is dependent on the inflammation and can constitute the course of ER stress. Bip-unfolded protein complex 3 [ER stress - inflammation]