has result has context has agent IRE - stress sensor (canonical)[ER stress - apotosis] endoplasmic reticulum stress [toxic course] receiving signal in IRE1 signal transduction pathway [ILE1 pathway] receiving abnormal protein signal by IRE1 [ER stress - apoptosis] Receiving abnormal protein signal by IRE1 is a subtype of receiving signal: A process that recognizes another object and changes into an abnormal protein (e.g., misfolded protein, etc.) signal by IRE1. This process is dependent on the apoptosis and can constitute the course of ER stress. IRE1 signaling (primitive) [ER stress - apoptosis] ER stress dependent process (molecular level)