has part has pathway IRE1 signaling (integrated pathway) IRE1 pathway [ER stress - apoptosis] IRE1-Traf2-ASK-JNK-Bcl2 pathway [ER stress - apoptosis] IRE1-TRAF2-ASK1 complex A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). http://purl.obolibrary.org/obo/GO_1990604 IRE1-Traf2-ASK-JNK-Bcl2 pathway is a subtype of IRE1 signaling (integrated pathway): Sequence of linked reactions, which has IRE1-Traf2-ASK-JNK-BCL2 pathway and gene regulation. This pathway is dependent on the apoptosis and can constitute the course of ER stress. TRAF2 activation by IRE1 [ER stress - apoptosis - IRE1−TRAF2-ASK-JNK-Bcl2 pathway] ASK activation [ER stress - apoptosis - IRE1-TRAF2-ASK-JNK-Bcl2 pathway] JNK activation [ER stress - apoptosis - IRE1−TRAF2-ASK-JNK-Bcl2 pathway] Bcl2 inactivation by JNK [ER stress - apoptosis - IRE1-TRAF2-JNK pathway]