has output has result has agent ASK activation [IRE-TRAF2-ASK-JNK pathway] TRAF2 -IRE1 adaptor protein (canonical)[ER stress - apotosis -IRE1-JNK] ASK activation [ER stress - apoptosis - IRE1-TRAF2-ASK-JNK-Bcl2 pathway] ASK activation is a subtype of molecular activation: A process that changes the activity of one of the ASK (apoptosis signal-regulating kinase) family to be higher. This process is dependent on the apoptosis and can constitute the course of ER stress. PMID:12843613 PMID:25232821 JNK activation [ER stress - apoptosis - IRE1−TRAF2-ASK-JNK-Bcl2 pathway] ASK - signaling factor (canonical)[ER stress - apotosis -TRAF2]