has result has context has pathway cell death (toxic course) cell death dependent process intrinsic apotosis signaling (primitive) Intrinsic apoptosis signaling (primitive) is a subtype of signaling [biological]: A process in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The process starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.). This process is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). This entity is a specific course-dependent process. This process can constitute the course of Cell death. Reactome:R-HSA-109606.3 intrinsic apoptotic signaling pathway [cell death] intrinsic apoptosis signaling (primitive) apoptosome assembly [Cell death]