has part intrinsic apoptotic signaling pathway release of cytochrome c from mitochondria [Cell death] intrinsic apoptotic signaling pathway [cell death] A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). This pathway is a specific course-dependent and can constitute the course of cell death. Reactome:Id: R-HSA-109606.3 Activation and oligomerization of BAK protein [cell death] Activation, translocation and oligomerization of BAX [cell death]