occurs in has result has context mitochondrial outer membrane endoplasmic reticulum stress [toxic course] release of cytochrome c from mitochondria [ER stress] Bax/Bak complex formation [ER stress] BAX and BAK homo-oligomerize at the ER membrane, leading to its permeabilization and the release of ER luminal proteins to the cytosol. BAX/BAK formed a protein complex with the cytosolic domain of IRE1alpha that was essential for IRE1alpha activation. Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR. Bax/Bak complex formation is a subtype of protein complex assembly: A process that forms a complex consisting of BAX/BAK, a member of the Bcl-2 family. This entity is a specific course-dependent process. This process can constitute the course of ER stress. Mitochondrial cytochrome c release can also be mediated by BAK and BAX which oligomerize and form a pore in the outer mitochondrial membrane, given the appropriate pro-apoptotic signals. BAX and BAK can also insert into the ER membrane to mediate Ca2+ release into the cytosol activating calpains. PMID:29472455 Bax-Bak complex formation ER stress dependent process (molecular level)