has role cyclosporin A cholestasis dependent chemical compound inhibitor role of BSEP bile acid transport cyclosporineA [Cholestasis] Cyclosporine, an MDR1 substrate, can cause cholestatic liver injury through a number of different mechanisms: i) Competitive inhibition of ATP dependent transporters, ii) Iinhibition of intrahepatic vesicle transport and targeting of ATP dependent transporters to the canalicular membrane and iii) Impairment of bile secretion partly by increasing canalicular membrane fluidity without affecting the expression of canalicular transporter. DrugBank:DB00091 InChIKey:PMATZTZNYRCHOR-CGLBZJNRSA-N cyclosporine reduces the expression of glutathione synthesizing enzymes and the canalicular glutathione efflux system, MRP2, leading to reduced bile salt-independent bile flow rifampicin, cyclosporine A, rifamycin SV, bosentan, troglitazone, erythromycin estolate, and glibenclamide inhibit Bsep in rats