has participant has context Activation and oligomerization of BAK protein cell death (toxic course) cell death dependent process Activation and oligomerization of BAK protein [cell death] Activation and oligomerization of BAK protein is a subtype of molecular subpathway. This entity is a specific course-dependent process. This process can constitute the course of Cell death. Mitochondrial cytochrome c release can also be mediated by BAK and BAX which oligomerize and form a pore in the outer mitochondrial membrane, given the appropriate pro-apoptotic signals. BAX and BAK can also insert into the ER membrane to mediate Ca2+ release into the cytosol activating calpains. PMID:29472455 Reactome:R-HSA-114294.2 tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux. BAK1 (canonical)[apotosis] BID (canonical)[apotosis]