has result has context glutathione depletion [toxic course] glutathione depletion dependent process reactive oxygen species biosynthetic process [Glutathione depletion] kupffer cell activation kupffer cell activation [Glutathione depletion] Chronic ethanol exposure increases the gut permeability, resulting in translocation of gut endotoxin/LPS to liver. In liver, LPS leads to KCs activation via activating NOX and the TLR-4 pathway. The activated KCs then produce a large amount of reactive oxygen species (ROS), pro-inflammatory cytokines, and chemokines, which finally lead to liver injury Kupffer cell activation is a subtype of macrophage activation: A change in morphology and behavior of a kupffer cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. This entity is a specific course-dependent process. This process can constitute the course of Glutathione depletion.