has participant has result has context has pathway signaling [biological] (primitive) intrinsic apoptotic signaling pathway cell death (toxic course) apoptotic process [Cell death] JUN (canonical)[Cell death] intrinsic apoptosis signaling (primitive) Intrinsic apoptosis signaling (primitive) is a subtype of signaling [biological]: A processin which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The process starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.). This process is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).