relateds assay has related human gene FNDC4 in vitro (human) 24hr phospholipidosis dependent molecule (HepG2_24h_sawada) FNDC4 (human)[Phospholipidosis] FRCP1 [Phospholipidosis] Fibronectin Type III Domain Containing 4 [Phospholipidosis] PMID:27066907 http://www.ncbi.nlm.nih.gov/gene/64838 NCBI-Human-GeneID:64838 http://omim.org/entry/611905 FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. FNDC4 (mol)