has role relateds assay has related human gene AP1S1 in vitro (human) 24hr phospholipidosis dependent molecule (HepG2_24h_sawada) AP1S1 (human)[Phospholipidosis] Adaptor Protein Complex AP-1 Subunit Sigma-1A [Phospholipidosis (Sawada)] PMID:10069802 PMID:11031247 PMID:9733768 The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008] Clathrin-coated vesicles that form on the trans-Golgi network (TGN)1 concentrate newly synthesized lysosomal hydrolases for transport from the Golgi system to the endosome compartment. The endosomes then deliver the hydrolases to the lysosome The formation of clathrin coats depends on the recruitment of the Golgi-specific adaptor protein complex AP-1 onto the cytosolic face of the TGN. NCBI-Human-GeneID:1174 http://www.ncbi.nlm.nih.gov/gene/1174 transporter AP1S1 (mol)