cytoplasmic alternation [Liver Pathological Findings] eosinophilic change [Liver Pathological Findings] Eosinophilic change [Liver PathologicalFindings] is a type of finding observed in hepatocyte cytoplasm. Based on pathological morphology, lesions are stained with eosin. acidophilic change · Stained with eosinophilic (eosinophilic) dye of hepatic cytoplasm. · Generally, it is caused by diffuse or focal increase of cytoplasmic organelle or excessive accumulation of eosinophilic substance. · Eosinophilic staining area: It often corresponds to mitochondria, smooth endoplasmic reticulum, or peroxisome. · Changes over the entire cytoplasm: granule degeneration, eosinophilic granular change, glute-like change · Cytoplasmic local changes: vitreous, eosinophilic inclusion bodies etc.