has part has core process apoptosis [liver tumor via ground glass appearance] hyperfunction of cell survival [Ground glass appearance] cell cycle G1/S phase transition [Ground glass appearance] increasing demand for response to oxidative stress [Ground glass appearance] DNA damage [Ground glass appearance] regulation of cell cycle [Ground glass appearance] decreasing negative regulator of G1/S transition [Ground glass appearance] cell cycle DNA replication initiation [Ground glass appearance] glucose homeostasis imbalance [Ground glass appearance] hypoxia [Ground glass appearance] tumorigenesis [Ground glass appearance] tumor growth [Ground glass appearance] tumor cell proliferation [Ground glass appearance] increasing number of dead cells in liver [Ground glass appearance] metastasis [Ground glass appearance] increasing distance between hepatocytes [Ground glass appearance] ground glass appearance with Cytochrome P450 activation by phenobarbital phenobarbital accumulation in liver [Ground glass appearance (severe)] smooth endoplasmic reticulum proliferation in hepatocyte (sustained) [Ground glass appearance] carcinogenesis [Ground glass appearance] hepatocyte proliferation (sustained) [Ground glass appearance] negative regulation of apoptotic process (sustained) [Ground glass appearance] negative regulation of autophagy (sustained) [Ground glass appearance] cell survival-cell death imbalance [Ground glass appearance] negative regulation of adherens junction assembly [Ground glass appearance] hyperfunction of phenobarbital metabolism phase I by Cytochrome P450 (sustained) [Ground glass appearance] smooth endoplasmic reticulum membrane organization (sustained) [Ground glass appearance] hyperfunction of glucuronic acid conjugation for phenobarbital intermediate metabolite (sustained) [Ground glass appearance] reactive oxygen species biosynthetic process (sustained) [Ground glass appearance] mitochondrial dysfunction [Ground glass appearance] necrosis [Ground glass appearance] phenobarbital metabolism imbalance [Ground glass appearance (severe) - tumorigenesis] regulation of generation of precursor metabolites and energy (sustained) [Ground glass appearance] phenobarbital induced liver tumor via ground glass appearance PMID:22723046 PMID:24180433 The totality of all processes through which ground glass appearance is realized. This toxic course has a process of CYP activation by phenobarbital and manifests liver tumor. AMPK activation (sustained) [Ground glass appearance]