has part smooth endoplasmic reticulum proliferation in hepatocyte smooth endoplasmic reticulum proliferation in hepatocyte [Ground glass appearance - Cyp] smooth endoplasmic reticulum proliferation in hepatocyte [Ground glass appearance - Cyp - PB] Smooth endoplasmic reticulum proliferation in hepatocyte is a subtype of endoplasmic reticulum proliferation in hepatocyte: A process that becomes larger in the number of smooth endoplasmic reticulum in hepatocyte(s). This process is dependent on the phenobarbital induced CYP activation and can constitute the course of Ground glass appearance. regulation of generation of precursor metabolites and energy by phenobarbital [Ground glass appearance]