liver cancer dependent molecule Tyms [Hepatocarcinogenesis] thymidylate synthetase [Hepatocarcinogenesis] http://omim.org/entry/188350 Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008] https://www.ncbi.nlm.nih.gov/gene/7298 NCBI-Mouse-GeneID:22171 NCBI-Rat-GeneID:29261 NCBI-Human-GeneID:7298 Tyms (mol)