has participant has result has context DNA damage mitochondrial respiratory chain abnormality [Mitochondrial disorder] mitochondrial damage [toxic course] mitochondrial disorder dependent process reactive oxygen species biosynthetic process [Mitochondrial disorder] cell death [Mitochondrial disorder] DNA damage [Mitochondrial disorder] Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. This entity is a specific course-dependent process. This process can constitute the course of Mitochondrial disorder. PMID:21145849 PMID:23299992 PMID:29222479 PMID:31623280 tumorigenesis [Mitochondrial disorder] Acetaminophen [mitochondrial disorder] troglitazone [mitochondrial disorder]