has output has result has context tumor necrosis factor production increasing volume of mitochondria [Mitochondrial disorder] mitochondrial damage [toxic course] mitochondrial disorder dependent process DNA damage [Mitochondrial disorder] Negative regulation of respiratory complex proteins synthesis tumor necrosis factor production [mitochondrial disorder] PMID:23299992 PMID:25339807 PMID:29222479 PMID:31623280 The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. This entity is a specific course-dependent process. This process can constitute the course of mitochondrial disorder. Inflammatory response [mitochondrial disorder] mitochondria morphology change [mitochondrial disorder] TNFΑ (canonical)[mitochondrial disorder] HIF1A activation [mitochondrial disorder] inducible nitric oxide synthase production [mitochondrial disorder]