has part toxic course Tumor-associated macrophage activation@hepatocarcinogenesis hepatocarcinogenesis [toxic course] The totality of all processes through which hepatocarcinogenesis is realized. under construction CCL2 production [Hepatocarcinogenesis] NfkB signaling (primitive) [hepatocarcinogenesis] TLR9 signaling [hepatocarcinogenesis] release of DNA from mitochondria [hepatocarcinogenesis] mitochondrial fission [hepatocarcinogenesis] Increasing IL-6 level [hepatocarcinogenesis] tumorigenesis [hepatocarcinogenesis] chemokine (C-X-C motif) ligand 8 production [hepatocarcinogenesis] Snail1 signaling [hepatocarcinogenesis] negative regulation of apoptotic process [hepatocarcinogenesis] Increasing ACSL1 level [hepatocarcinogenesis] HNF4A inactivation [hepatocarcinogenesis] positive regulation of cell division [hepatocarcinogenesis] tumor cell invasion [hepatocarcinogenesis] Increasing ACSL4 level [hepatocarcinogenesis] Increasing COX-2 level [hepatocarcinogenesis] positive regulation of arachidonic acid metabolic process [hepatocarcinogenesis] Increasing AGGF1 level [hepatocarcinogenesis] Increasing VEGF level [hepatocarcinogenesis] AGGF1 signaling [hepatocarcinogenesis] AKT signaling (primitive) [hepatocarcinogenesis] GSK3beta signal (primitive) [hepatocarcinogenesis] TOR signaling (primitive)　[hepatocarcinogenesis] p38 signaling (primitive) [hepatocarcinogenesis] Metalloprotease activation [hepatocarcinogenesis] epithelial to mesenchymal transition [hepatocarcinogenesis] negative regulation of APC signaling [hepatocarcinogenesis] negative regulation of EPCR signaling [hepatocarcinogenesis] ATF4 inactivation [hepatocarcinogenesis] PMAIP1 inactivation [hepatocarcinogenesis] ATF6 signaling (primitive) [hepatocarcinogenesis] Grp78 signaling (primitive) [hepatocarcinogenesis] Increasing BCL-2 level [hepatocarcinogenesis] CAR activation [hepatocarcinogenesis] CCL2 signaling (primitive) [hepatocarcinogenesis] hepatic cirrhosis [hepatocarcinogenesis] Increasing CCND1 level [hepatocarcinogenesis] positive regulation of cell cycle [hepatocarcinogenesis] Increasing CDK2 level [hepatocarcinogenesis] CDT1 inactivation [hepatocarcinogenesis] Removing damaged DNA stress [hepatocarcinogenesis] Decreasing CXCL8 level [hepatocarcinogenesis] negative regulation of cellular senescence [hepatocarcinogenesis] metastasis [hepatocarcinogenesis] CXCR3 signaling [hepatocarcinogenesis] endothelial progenitor cell mobilization [hepatocarcinogenesis] Increasing CXCR4 level [hepatocarcinogenesis] JNK signaling (primitive) [hepatocarcinogenesis] Decreasing CYP1A2 level [hepatocarcinogenesis] Hypofunction of 17β-Estradiol metabolic process [hepatocarcinogenesis] DNA alkylation [hepatocarcinogenesis] formation of DNA adducts [hepatocarcinogenesis] DNA damage [hepatocarcinogenesis] proto-oncogene mutation [hepatocarcinogenesis] tumor suppressor gene mutation [hepatocarcinogenesis] negative regulation of DNA repair [hepatocarcinogenesis] induction of genomic instability [hepatocarcinogenesis] Hyperfunction of DNA biosynthesis [hepatocarcinogenesis] DNA replication [hepatocarcinogenesis] Tumor cell proliferation [Hepatocarcinogenesis] Increasing DNMT1 level [hepatocarcinogenesis] Increasing DPYD level [hepatocarcinogenesis] EGFR signaling (primitive) [hepatocarcinogenesis] sorafenib resistance (process) [hepatocarcinogenesis] ERK signaling (primitive) [hepatocarcinogenesis] negative regulation of gap-junctional intercellular communication [hepatocarcinogenesis] increasing demand for response to ER stress [hepatocarcinogenesis] inflammatory response [hepatocarcinogenesis] increasing demand for response to oxidative stress [hepatocarcinogenesis] FAK signaling (primitive) [hepatocarcinogenesis] FGF2 signaling (primitive) [hepatocarcinogenesis] WNT signaling (primitive) [hepatocarcinogenesis] Decreasing GADD45G level [hepatocarcinogenesis] Increasing GDF15 level [hepatocarcinogenesis] Decreasing GPHN level [hepatocarcinogenesis] beta-catenin signaling (primitive) [hepatocarcinogenesis] cisplatin resistance [hepatocarcinogenesis] Increasing HBEGF level [hepatocarcinogenesis] HBV infection [hepatocarcinogenesis] Notch signaling [hepatocarcinogenesis] STAT3 signaling (primitive) [hepatocarcinogenesis] TGF beta receptor signaling (primitive) [hepatocarcinogenesis] c-Src signaling (primitive) [hepatocarcinogenesis] telomerase reverse transcriptase gene mutation [hepatocarcinogenesis] necrosis [hepatocarcinogenesis] dysregulation of immune balance [hepatocarcinogenesis] hepatocyte regeneration [hepatocarcinogenesis] HCV infection [hepatocarcinogenesis] Increasing MIR135A level [hepatocarcinogenesis] PPARalpha activation [hepatocarcinogenesis] HGFR signaling (primitive) [hepatocarcinogenesis] Increasing HGF level [hepatocarcinogenesis] neovascularization [hepatocarcinogenesis] HHIP inactivation [hepatocarcinogenesis] Increasing HILPDA level [hepatocarcinogenesis] Increasing iron uptake level [hepatocarcinogenesis] Increasing HULC level [hepatocarcinogenesis] Increasing PPARA level [hepatocarcinogenesis] Hedgehog signaling [hepatocarcinogenesis] neoplastic cell transformation [hepatocarcinogenesis] glycolytic process [hepatocarcinogenesis] Hippo signaling (primitive) [hepatocarcinogenesis] YAP signaling (primitive) [hepatocarcinogenesis] IFN alpha inactivation [hepatocarcinogenesis] IGFBP3 inactivation [hepatocarcinogenesis] IL-6 inactivation [hepatocarcinogenesis] KIAA0101 inactivation [hepatocarcinogenesis] JAK signaling (primitive) [hepatocarcinogenesis] IL1 signaling (primitive) [hepatocarcinogenesis] IL-6 signaling [hepatocarcinogenesis] Iron accumulation [hepatocarcinogenesis] IP-10 signaling (primitive) [hepatocarcinogenesis] Increasing JUN level [hepatocarcinogenesis] JUN gene promoter demethylation [hepatocarcinogenesis] negative regulation of autophagy [hepatocarcinogenesis] Increasing KIAA0101 tv1 level [hepatocarcinogenesis] negative regulation of signal transduction by p53 class mediator [hepatocarcinogenesis] Decreasing LDLRAD4 level [hepatocarcinogenesis] LDLRAD4 gene promoter methylation [hepatocarcinogenesis] PTPRD inactivation [hepatocarcinogenesis] MMP7 signaling (primitive) [hepatocarcinogenesis] Increasing MYC level [hepatocarcinogenesis] MYC gene promoter demethylation [hepatocarcinogenesis] UHRF1 production [hepatocarcinogenesis] ORC1 inactivation [hepatocarcinogenesis] Increasing PANDA level [hepatocarcinogenesis] PCK1 inactivation [hepatocarcinogenesis] Increasing PCNA level [hepatocarcinogenesis] PHB inactivation [hepatocarcinogenesis] PI3K signaling (primitive) [hepatocarcinogenesis] PIM3 activation [hepatocarcinogenesis] changing abnormal cellular structure [hepatocarcinogenesis] liver malfunction [hepatocarcinogenesis] lipid storage in liver [hepatocarcinogenesis] negative regulation of caspase-3 activation [hepatocarcinogenesis] Decreasing PROC level [hepatocarcinogenesis] PROC gene promoter methylation [hepatocarcinogenesis] Increasing PROM1 level [hepatocarcinogenesis] Increasing PROX1 level [hepatocarcinogenesis] STAT3 activation [hepatocarcinogenesis] PTPRD gene promoter methylation [hepatocarcinogenesis] Increasing PVT1 level [hepatocarcinogenesis] Decreasing MIR150 level [hepatocarcinogenesis] increasing production quantity of ROS [hepatocarcinogenesis] SFRP1 inactivation [hepatocarcinogenesis] Increasing SPTLC3 level [hepatocarcinogenesis] positive regulation of cancer stem cell division [hepatocarcinogenesis] TAZ signaling (primitive) [hepatocarcinogenesis] Hepatic fibrosis [hepatocarcinogenesis] TGF-alpha signaling (primitive) [hepatocarcinogenesis] regulatory T cell migration [hepatocarcinogenesis] TNF signaling (primitive) [hepatocarcinogenesis] response to hypoxia [hepatocarcinogenesis] negative regulation of TSLC signaling [hepatocarcinogenesis] negative regulation of actin cytoskeleton organization [hepatocarcinogenesis] Negative regulation of adherens junction assembly [hepatocarcinogenesis] Twist1 signaling (primitive) [hepatocarcinogenesis] UHRF1 inactivation [hepatocarcinogenesis] actin cytoskeleton reorganization [hepatocarcinogenesis] cytoplasmic sequestering of cyclin A [hepatocarcinogenesis] Malfunctioning of centrosome duplication [hepatocarcinogenesis] Malfunctioning of cytokinesis [hepatocarcinogenesis] Cancer-stem like cell proliferation [hepatocarcinogenesis] Tumor suppressor inactivation [hepatocarcinogenesis] aflatoxin metabolic process [hepatocarcinogenesis] tumor cell survial [hepatocarcinogenesis] alcohol intake [hepatocarcinogenesis] autophagy [hepatocarcinogenesis] Connexin signaling (primitive) [hepatocarcinogenesis] negative regulation of connexin signaling [hepatocarcinogenesis] Negative regulation of sphingolipid metabolic process [hepatocarcinogenesis] mitochondrial dysfunction [hepatocarcinogenesis] Negative regulation of methionine metabolic process [hepatocarcinogenesis] lipoperoxidation [hepatocarcinogenesis] tumor malignancy alteration [hepatocarcinogenesis] hypoxia [hepatocarcinogenesis] hypofunction of immune response to tumor cell [hepatocarcinogenesis] protooncogene activation [hepatocarcinogenesis] response to endoplasmic reticulum stress [hepatocarcinogenesis] negative regulation of ROS formation [hepatocarcinogenesis] cellular damage [hepatocarcinogenesis] nodule formation [hepatocarcinogenesis] Increasing lipid [hepatocarcinogenesis] iron metabolic dysfunction [hepatocarcinogenesis]