has participant has result has context DNA alkylation liver carcinogenesis dependent process hepatocarcinogenesis [toxic course] tumorigenesis [hepatocarcinogenesis] DNA alkylation [hepatocarcinogenesis] PMID:2919404 The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. This entity is a specific course-dependent process. This process can constitute the course of hepatocarcinogenesis. chloroethene [hepatocarcinogenesis]