has result manifests phenotype has context has agent DNA replication number of objects liver carcinogenesis dependent process hepatocarcinogenesis [toxic course] DNA replication [hepatocarcinogenesis] PMID:29270806 PMID:30166860 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. This entity is a specific course-dependent process. This process can constitute the course of hepatocarcinogenesis. Tumor cell proliferation [Hepatocarcinogenesis] FEN1 (human) [hepatocarcinogenesis]