has participant has output has result has context PPARalpha activation liver carcinogenesis dependent process hepatocarcinogenesis [toxic course] tumorigenesis [hepatocarcinogenesis] clofibrate [hepatocarcinogenesis] PPARalpha activation [hepatocarcinogenesis] PMID:18188449 PPARalpha activation is a subtype of activating nuclear receptor: A process that changes the activity of the activating PPAR alpha ( (Peroxisome Proliferator Activated Receptor Alpha)) with a nuclear receptor role to be higher. This entity is a specific course-dependent process. This process can constitute the course of hepatocarcinogenesis. Reactome The set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor elements (PPREs) in their promoters and include: 1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2); 2) genes involved in fatty acid transport (Cd36, , Slc27a1, Fabp1, Cpt1a, Cpt2); 3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1); 4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5); 5) genes involved in triglyceride clearance ( Angptl4); 6) genes involved in glycerol metabolism (Gpd1 in mouse); lipid storage in liver [hepatocarcinogenesis] PPARA - activation state (mouse) [hepatocarcinogenesis]