has input has output has result has context has agent aflatoxin metabolic process liver carcinogenesis dependent process hepatocarcinogenesis [toxic course] tumor suppressor gene mutation [hepatocarcinogenesis] aflatoxin B1 [hepatocarcinogenesis] aflatoxin metabolic process [hepatocarcinogenesis] PMID:19590965 PMID:24078988 PMID:29301315 PMID:31439937 The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. This entity is a specific course-dependent process. This process can constitute the course of hepatocarcinogenesis. aflatoxin metabolism aflatoxin B1 exo-8,9-epoxide [hepatocarcinogenesis] CYP1A2(canonical) [hepatocarcinogenesis] CYP2A13 (canonical) [hepatocarcinogenesis] CYP2A6 (canonical) [hepatocarcinogenesis] CYP3A4(canonical) [hepatocarcinogenesis] CYP3A5(canonical) [hepatocarcinogenesis] CYP3A7 (canonical) [hepatocarcinogenesis] Cyp1A1 (canonical) [hepatocarcinogenesis]