4-hydroxynonenal mitochondria disorder dependent chemical compound 4-hydroxynonenal [mitochondrial disorder] 4-hydroxy-trans-2-nonenal A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group. PMID:23299992 PMID:25339807