enzyme-linked receptor protein signaling pathway cell surface receptor protein tyrosine kinase signaling pathway https://github.com/geneontology/go-ontology/issues/26955 The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. GO:0007169 Reactome:R-HSA-187015 transmembrane receptor protein serine/threonine kinase signaling pathway transmembrane receptor protein tyrosine kinase signalling pathway