negatively regulates nucleotide biosynthetic process negative regulation of biosynthetic process regulation of nucleotide biosynthetic process negative regulation of nucleotide biosynthetic process down regulation of nucleotide biosynthetic process GO:0030809 inhibition of nucleotide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. negative regulation of nucleotide anabolism downregulation of nucleotide biosynthetic process negative regulation of nucleotide formation negative regulation of nucleotide biosynthesis down-regulation of nucleotide biosynthetic process negative regulation of nucleotide synthesis negative regulation of nucleotide metabolic process biological regulation