regulates (processual) regulates microtubule depolymerization regulation of microtubule polymerization or depolymerization regulation of microtubule depolymerization Any process that modulates the frequency, rate or extent of microtubule depolymerization. GO:0031114 regulation of microtubule disassembly biological regulation regulation of protein depolymerization regulation of supramolecular fiber organization