G protein-coupled receptor signaling pathway somatostatin receptor signaling pathway GO:0038169 bf SST receptor signaling pathway 2012-06-12T10:30:01Z SSTR signaling pathway A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process. In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'.