in taxon negatively regulates insulin secretion negative regulation of insulin secretion inhibition of insulin secretion down regulation of insulin secretion down-regulation of insulin secretion downregulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. Reactome:R-HSA-400042 GO:0046676 negative regulation of protein secretion regulation of insulin secretion biological regulation negative regulation of peptide hormone secretion Eumetazoa