located in located in develops from develops from filtered through cerebrospinal fluid BTO:0000237 EHDAA2 models this as developing from CP, which is wrong cerebral spinal fluid TAO:0002184 Portion of organism substance that is a clear fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.[TAO] GAID:1181 NCIT:C12692 many sources state the CP as sole producer of CSF, but this is disputed [DOI:10.1007/s11064-015-1581-6] liquor cerebrospinalis CSF UMLS:C0007806 MA:0002503 ZFA:0001626 FMA:20935 In vertebrates, at early stages of Central Nervous System (CNS) development, the architecture of the brain primordium reveals the presence of the cavity of brain vesicles, which is filled by Embryonic Cerebro-Spinal Fluid (E-CSF). (...) Rat and chick E-CSF proteomes are similar, although rat is more complex in certain groups of proteins, e.g., apolipoproteins, which may be involved in the control of neural diversity, and has soluble enzymes present, just like adult human CSF, but unlike chick E-CSF, revealing phylogenetic brain differences between these groups of vertebrates.[uncertain][VHOG] A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord. EFO:0000329 EV:0100311 CALOHA:TS-0130 VHOG:0001278 spinal fluid Wikipedia:Cerebrospinal_fluid ENVO:02000029 the FMA def states that this is subarachnoid spaces only. ZFA def states subarachnoid spaces and brain ventricles, but not SC (and has part_of to brain). Circulation: It circulates from the lateral ventricles to the foramen of Monro (Interventricular foramen), third ventricle, aqueduct of Sylvius (Cerebral aqueduct), fourth ventricle, foramen of Magendie (Median aperture) and foramina of Luschka (Lateral apertures), subarachnoid space over brain and spinal cord. It should be noted that the CSF moves in a pulsatile manner throughout the CSF system with nearly zero net flow. CSF is reabsorbed into venous sinus blood via arachnoid granulations. BIRNLEX:1798 UBERON:0001359 EHDAA2:0004441 MAT:0000499 MESH:D002555 choroid plexus choroid plexus of lateral ventricle ventricular system of central nervous system transudate