part of part of has potential to develop into has potential to develop into pigmented layer of retina optic cup presumptive retinal pigmented epithelium future pigmented retinal epithelium future retinal pigmented epithelium future PRE outer layer optic cup UBERON:0005424 presumptive pigmented epithelia VHOG:0000492 optic cup outer layer EMAPA:16677 future pigmented layer EHDAA2:0001306 presumptive pigmented epithelium future RPE (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] TAO:0000064 ZFA:0000064 Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium. presumptive structure